Vigabatrin Associated Retinal Pathology
نویسندگان
چکیده
منابع مشابه
Vigabatrin associated retinal dysfunction in children with epilepsy.
BACKGROUND Recent reports have established that eye changes occur in patients treated with vigabatrin. AIM To identify the eye changes associated with vigabatrin, based on a prospective study of children treated for seizures. METHODS Twenty nine children on vigabatrin (mainly as add on therapy) were followed up for 6.5 years. Ophthalmic examination was performed before starting treatment an...
متن کاملReduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.
PURPOSE To determine whether visual functions are decreased in children with infantile spasms and vigabatrin-attributed retinal toxicity. METHODS Contrast sensitivity and grating acuity were measured by using sweep visual evoked potential (VEP) testing in 42 children with infantile spasms (mean age, 29.23 +/- 18.31 months). All children had been exposed to vigabatrin (VGB) for a minimum of 1 ...
متن کاملVisual field defects associated with vigabatrin therapy.
OBJECTIVE To estimate the prevalence of visual field defects in patients taking the anticonvulsant drug vigabatrin and to characterise the features of visual dysfunction found. METHODS Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. A control group of 16 patients with epilepsy u...
متن کاملOuter retinal dysfunction in patients treated with vigabatrin.
OBJECTIVE To assess early visual impairment related to vigabatrin prospectively in patients with and without visual symptoms. BACKGROUND Vigabatrin acts as an inhibitor of gamma-aminobutyric acid (GABA) transaminase. GABA-induced ion transport changes in the retinal pigment epithelium have been described. The electro-oculogram (EOG) is a clinical test that reflects photoreceptor and pigment e...
متن کاملRetinal function abnormalities in patients treated with vigabatrin.
OBJECTIVE To evaluate central and peripheral retinal function in patients treated with vigabatrin, an antiepileptic drug associated with peripheral visual field constriction (VFC). METHODS Six patients with epilepsy treated with vigabatrin as add-on therapy for at least 3 years were included in this observational case series. All patients underwent a clinical ophthalmologic examination, color...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2002
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-16-1-2